Some antidepressants may risk breast cancer return from AP reports that women taking Prozac, Paxil or Zoloft along with Tamoxifen wipes out the effectiveness of Tamoxifen and thus promote the return of the breast cancer.
The federal Food and Drug Administration has been considering a change to tamoxifen's label to warn about the antidepressants drugs and a gene variation some women have that can make tamoxifen less effective. An advisory panel unanimously recommended a change in 2006, but the agency is still considering it.
"This is a very controversial area," said Dr. Claudine Isaacs, a breast specialist at Georgetown University's Lombardi Comprehensive Cancer Center. "Until these data are absolutely clear, I would avoid drugs that impact on tamoxifen metabolism."
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